In .NET Core (and post), there is no longer the ability to create custom AppDomains. You can use [AssembyLoadContext](https://learn.microsoft.com/en-us/dotnet/api/system.runtime.loader.assemblyloadcontext), or processes, or [WebAssembly](https://github.com/SteveSandersonMS/DotNetIsolator).
I created a simple project for doing this: <https://developmentwithadot.blogspot.com/2025/10/introducing-isolator-framework-for.html>.

In .NET, there is no longer the ability to create custom AppDomains or .NET Remoting. You can use [AssembyLoadContext](https://learn.microsoft.com/en-us/dotnet/api/system.runtime.loader.assemblyloadcontext) or processes, or [WebAssembly](https://github.com/SteveSandersonMS/DotNetIsolator).
I created a simple project for doing this: <https://developmentwithadot.blogspot.com/2025/10/introducing-isolator-framework-for.html>.